ABSTRACT
Objective: The hepatoprotective role of Tylophora indica ethanolic extract was studied on artesunate induced liver injury in wistar albino rats. Methods: Liver toxicity was induced by administering artesunate110mg/kg orally for 14 days in wistar albino rats. Ethanolic (90%) extracts of Tylophora indica (EETI) was administered orally to the experimental animals for 14 days. The hepatoprotective activity of the extracts was assessed by analyzing the levels of various biochemical parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkalinephosphatase (ALP), γ‐glutamyltransferase (GGT), bilirubin (BIL) and albumin (ALB) in serum. Meanwhile thelevels of antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT) were measured in rat liver homogenate. Results: The results showed that on administration of artesunate for 14 days caused a significant increase (p<0.001) in the levels of ALT, AST, ALP and GGT in serum. The levels of SOD and CAT in liver homogenate were also decreased significantly (p<0.01) in artesunate administered animals. The levels of above biochemical parameters were significantly (p< 0.001) reversed in rats which received EETI. Conclusions: The present study proves that the ethanolic extract of Tylophora indica has a significant protective action against artesunate induced hepatic injury.